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Immunology & Inflammation

NB-003: CD38-Targeting Antibody

NB-015: Topical JAK1/Tyk2 Dual Inhibitor for Atopic Dermatitis

NB-015: Topical JAK1/Tyk2 Dual Inhibitor for Atopic Dermatitis

A first-in-class humanized monoclonal antibody targeting CD38 for the treatment of multiple myeloma (MM) and autoimmune diseases. With FDA IND approval secured, this program addresses an $8B market opportunity with strong global patent protection.

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NB-015: Topical JAK1/Tyk2 Dual Inhibitor for Atopic Dermatitis

NB-015: Topical JAK1/Tyk2 Dual Inhibitor for Atopic Dermatitis

NB-015: Topical JAK1/Tyk2 Dual Inhibitor for Atopic Dermatitis

  Targets both the TH2 and TH1 pathways, the primary drivers of AD pathology. This differentiated dual-inhibitor approach is designed to deliver broader and more durable therapeutic response than single-pathway agents. 

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NB-016: First-in-class small-molecule MyD88 inhibitor

NB-015: Topical JAK1/Tyk2 Dual Inhibitor for Atopic Dermatitis

NB-016: First-in-class small-molecule MyD88 inhibitor

  Novel mechanism targeting innate immune signaling at its molecular origin. A New Chemical Entity and the world's first small-molecule MyD88 inhibitor; set to enter clinical-stage compassionate use. Breakthrough results across multiple dermatological indications. 

No competitor has reached clinical use with a small-molecule MyD88 inhibitor.

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